Concering 134a, there is both pharma grade 134a and “technical grade” R 134a(industrial grade r134a).
The difference is below:
HFA Propellants / Aerosol Propellant HFA-134A for Medical Sprays including:
* MDIs (Metered Dose Inhalers) also known as pharmaceutical aerosols or asthma sprays for the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disorder) and respiratory infections
* nasal sprays for the treatment of allergic rhinitis
* foam sprays
*oral and topical sprays (e.g. nerve sensitisation, tooth vitality, pain relaxation)
*replace the fully halogenated ozone depleting chlorofluorocarbons
CFC 11, CFC 12 and CFC 114
traditionally used in medical sprays which are being phased out under the terms of the Montreal Protocol by the non-ozone depleting hydrofluoroalkanes HFA 134a ,which is also called Pharmaceutical HFA-134A (P)
While“Technical grade” R 134a(industrial grade r134a) is predominately used as refrigerant R134a and fire extinguishing agents .It is with:
*the higher purity obtained by additional manufacturing processes specifically developed and applied to meet the stringent specifications set out for pharmaceutical grade products,
*manufacturing in dedicated facilities according to the current good manufacturing practice guidelines,
*high-level quality control using analytical methods specifically developed to screen more than 60 impurities in the propellants at levels below one part per million,
* registration of the manufacturing processes and quality control systems according to the standards for drug active substances, although both Propellant Hfa (P) 134a for Inhaling and Spray Gas with DMF Certificate are classed as
exipients.
