Introduction to Propellant Norflurane HFA 134a aerosol in Pharmacy
Norflurane HFA 134a has become the propellant of choice in modern pharmaceutical aerosols following the global phase-out of ozone-depleting CFCs. Norflurane HFA 134a propellant combines excellent pharmaceutical properties with environmental safety, making it indispensable for:
Pressurized Metered-dose inhalers (pMDIs)
Topical medicinal sprays
Nasal drug delivery systems
Disinfectant and wound care aerosols
What is pMDI? How it works?
Pressurized metered dose inhaler (pMDI), also known as a puffer, is the most commonly used delivery device and is most effective when used with a spacer. The canister of a metered dose inhaler contains the medication in a solution or suspension. This pressurised canister is also filled with propellant norflurane HFA 134a, that do not react with the medication. When the canister is activated by pressing on the top of it when it is attached to the mouthpiece, a small amount of this gas is released and takes some of the medication with it. This vapour of air and medication is then channelled through the mouthpiece and delivered to the lungs when the patient inhales. Metered dose inhalers are designed so that each usage delivers a precise amount of medication. A dose counter may be included to indicate the number of doses that has been taken.
Key Pharmaceutical Advantages of hFA134a as aerosol spray propellant
1 Optimal Drug Delivery Characteristics
Particle size control: Generates 1-5 μm droplets ideal for pulmonary deposition
Dose consistency: <5% variability between actuations
Plume geometry: Produces soft, slow-moving clouds for improved lung deposition
Temperature stability: Maintains performance across 15-30°C range
2 Formulation Versatility
Compatible with:
Solution formulations (e.g., bronchodilators)
Suspension systems (e.g., corticosteroids)
Novel drug forms (nanoparticles, liposomes)
Allows use of ethanol (up to 15%) as cosolvent
Stable with common excipients (oleic acid, sorbitan trioleate)
3 Clinical Performance Benefits
Higher lung deposition: 40-60% vs 10-20% for CFC inhalers
Reduced oropharyngeal deposition: Minimizes local side effects
Faster onset: Particularly important for rescue medications
Improved taste profile: Better patient acceptance
Environmental Impact comparison
| Parameter | HFA 134a | CFC-11 | CFC-12 |
|---|---|---|---|
| ODP | 0 | 1 | 1 |
| GWP (100-yr) | 1430 | 4660 | 10200 |
| Atmospheric Lifetime | 14 yrs | 45 yrs | 100 yrs |
Propellant Norflurane HFA 134a Properties
|
tem |
Index |
results |
|
properities |
colorless gas, slight ether smell, odorless, liquid |
pass |
|
identification(1) |
rared spectrum meets requirem |
pass |
|
Identification(2) |
retention time of test gas's main peak is consist with that of reference gas's main peak |
pass |
|
purity of 1,1,1,2-tetrafluorethane,ω/% ≥ |
99.99 |
99.99 |
|
moisture,ω/% ≤ |
0.0010 |
0.0004 |
|
acidity(as HCL),ω/% ≤ |
0.00001 |
not detected |
|
high boiling residue,ω/% ≤ |
0.0005 |
0.0004 |
|
chloride(detection limit 0.0003%) |
no muddy |
pass |
|
non-condensable gas in gas phrase(25°C)/%(v/v) |
1.5 |
0.5 |
hFA134a propellant supplier Profile Tel：+086-592-5803997
Xiamen Juda is a leading provider of refrigeration solutions in China, offering a wide range of products such as Refrigerant Gas, Medical Aerosol Propellant, Cleaning Agent, Fire Extinguishing Agent, Welding Gas, Cooling Fluid and Fluoropolymer. Founded in 1988 by one of China's chemical manufacturing pioneers, Juhua Group Corporation, Xiamen Juda has been dedicated to exporting fluorinated chemicals since 2004. Our team is committed to excellence and providing top-notch solutions to meet the needs of our customers. We take pride in our longstanding reputation for quality and reliability. With Xiamen Juda, you can trust that you are getting the best in the industry.
aerosol propellant HFA 134A common Packing Tel：+086-592-5803997
30lb/13.6kg Disposable cylinder
926L Ton Cylinder
22 Ton ISOTANK
