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Norflurane HFA 134a Medicinal Aerosol Propellant Tel:+86-592-5803997
Norflurane, chemically known as 1,1,1,2-tetrafluoroethane (HFA 134a), is a hydrofluoroalkane (HFA) propellant widely used in pressurized metered-dose inhalers (pMDIs) for the administration of respiratory drugs. Following the phase-out of ozone-depleting chlorofluorocarbon (CFC) propellants under the Montreal Protocol, HFA 134a emerged as a safe and effective alternative.
Medicinal aerosols are pressurized dosage forms that deliver medication as fine particles or droplets, typically via inhalation or topical application. These formulations play a crucial role in treating respiratory diseases-such as asthma, chronic obstructive pulmonary disease (COPD), and infections-as well as in the administration of topical and nasal drugs. Their ability to provide rapid, targeted, and controlled drug delivery makes them indispensable in modern therapeutics.
Physicochemical Properties of Norflurane HFA 134a
Norflurane HFA 134a possesses several key characteristics that make it suitable for pharmaceutical aerosols:
| Property | Value/Description |
|---|---|
| Chemical formula | CF₃CH₂F |
| Molecular weight | 102.03 g/mol |
| Boiling point | -26.3 degrees (-15.3 degrees F) |
| Vapor pressure | ~5.7 bar at 20 degrees |
| Density | 1.21 g/cm³ (liquid at 25 degrees) |
| Ozone Depletion Potential (ODP) | 0 |
| Global Warming Potential (GWP) | 1430(lower than CFCs, but still a greenhouse gas) |
These properties ensure:
✔ Stability– It does not react with the majority of active pharmaceutical ingredients (APIs).
✔ Consistent drug delivery– It provides a uniform particle size distribution (1–5 µm for pulmonary deposition).
✔ Non-flammability– Safe for patient use.
Advantages of Norflurane HFA-134a in Medicinal Aerosols Tel:+86-592-5803997
1. Superior environmental profile compared to CFCs.
As the pharmaceutical aerosol industry moved away from ozone-depleting chlorofluorocarbons (CFCs), HFA 134a emerged as the propellant of choice due to its:
Zero ozone depletion potential (ODP): unlike CFC-11 (ODP=1) and CFC-12 (ODP=1), HFA 134a has no impact on the ozone layer.
Reduced atmospheric lifetime: 14 years, compared to 45–100 years for CFCs.
Regulatory compliance: It meets all requirements of the Montreal Protocol and subsequent amendments.
The transition to HFA 134a has prevented the equivalent of millions of metric tons of ozone-depleting substances from entering the atmosphere since the 1990s.
2. Optimized Medication Administration Performance
Norflurane HFA-134a offers significant therapeutic advantages in pulmonary drug delivery:
A. Enhanced pulmonary deposition
Generates particles in the ideal 1 to 5 μm range for deep lung penetration.
Achieves a lung deposition efficiency of 30% to 50%, compared to 10% to 20% with older CFC systems.
Allows for more consistent dosing throughout the lifespan of the canister.
B. Improved formulation stability
Its chemically inert nature preserves drug potency
Maintains suspension stability better than CFC propellants
Compatible with a wide range of APIs, including:
Bronchodilators (albuterol, salmeterol)
Corticosteroids (fluticasone, beclomethasone)
Combination therapies (fluticasone/salmeterol)
C. Consistent dose delivery
Delivers reliable performance
Maintains a consistent spray pattern and plume geometry
Less temperature-dependent than CFC propellants
HFA 134a Propellant Manufacturer– Factory tour Tel:+86-592-5803997
Supplier of Medicinal Aerosol Propellants – Company Profile Tel:+86-592-5803997
Standard Packaging Tel:+86-592-5803997
30 lb/13.6 kg disposable cylinder
926L Cylinder
22-tonne ISO tank
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