HFA 152a Medical gas, also known as 1,1,-difluoroethane. HFA 152a is a next-generation hydrofluoroalkane propellant with unique characteristics that make it ideal for pharmaceutical applications.
Medicinal Aerosol are pressurized dosage forms that deliver medication in the form of fine particles or droplets, typically through inhalation or topical application. These formulations play a critical role in treating respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and infections, as well as in topical and nasal drug delivery. Their ability to provide rapid, targeted, and controlled drug release makes them indispensable in modern therapeutics.
Core Characteristics & Advantages of HFA 152A 1,1,-difluoroethane
1. Superior Physicochemical Properties
| Parameter | HFA 152A Specifications |
|---|---|
| Chemical Name | 1,1-Difluoroethane |
| Molecular Formula | CH3CHF2 |
| Molecular Weight | 66.05 g/mol |
| Boiling Point | -24.7°C |
| Vapor Pressure (20°C) | 4.16 bar |
| Density (25°C) | 0.91 g/cm³ |
| ODP | 0 |
| GWP | 138 |
2. Pharmaceutical-Grade Purity Standards
Purity ≥99.9%
Water content ≤10ppm
Non-volatile residue ≤1ppm
Acidity (as HCl) ≤0.1ppm
Individual impurities ≤0.01%
Total impurities ≤0.1%
3. Performance Advantages
Excellent solubility: Compatible with various API formulations
Low global warming potential: GWP of only 138, offering environmental benefits
Superior stability: Compatible with common pharmaceutical excipients
Ideal vapor pressure: Ensures consistent spray performance
What Is The Difference Between HFA 152A And HFA 134A
It was observed that HFA 152a drives marginally faster plumes than HFA134a despite a slightly lower vapour pressure. Propellant boiling/cavitation behaviour appears similar for both propellants. The liquid/gaseous spray cones from each type of propellant behave similarly.
HFA 152a aerosol propellant ,though still HFA, is with much lower GWP 138, 10 times less than HFA-134a pharmaceutical grade. HFA-152a pharma grade is tested to be of a safe propellant for pMDI.
The inhaler dose release dynamics are broadly similar between the HFA134a and HFA152a propellants in placebo form in commercial actuators which suggests that HFA152a may be a suitable greener alternative
Basic Physical Properties Compared:
| FC No. | Formula | B.Pt ( °C ) | S.G. (g/cc, 20°C ) | ODP+ | +GWP | |
| CFC | 11 | CFCl3 | 23.7 | 1.49 | 1 | 4660 |
| CFC | 12 | CF2Cl2 | -29.8 | 1.33 | 1 | 10800 |
| HFA | 134a | CF3 -CFH2 | -26.2 | 1.23 | 0 | 1300 |
| HFA | 227ea | CF3 -CFH-CF3 | -16.5 | 1.41 | 0 | 3350 |
| HFA | 152a | CF2H-CH3 | -24.7 | 0.91 | 0 | 138 |
Why Choose Our HFA 152A Propellant
1. Quality Assurance System
cGMP manufacturing standards
Rigorous batch quality control
Complete Certificate of Analysis (CoA)
Complies with USP/EP/JP pharmacopeia standards
2. Technical Support
Formulation development assistance
Compatibility study support
Manufacturing process consultation
Regulatory registration guidance
3. Global Supply Capabilities
Stable production capacity
Flexible packaging options
Reliable logistics network
Responsive technical support
Contact Us
For more information about HFA 152A pharmaceutical-grade propellant, or to request samples and technical support, please contact:
Our address
Room 1102, Unit C, Xinjing Center, No.25 Jiahe Road, Siming District, Xiamen, Fujan, China
Phone Number
+86-592-5803997
Choose our HFA 152A pharmaceutical-grade propellant for superior performance and reliable quality assurance in your aerosol pharma products!
